Hypokalemic periodic paralysis (HOKPP) is a condition that causes episodes of muscle paralysisassociated with a fall in blood potassium levels (hypokalaemia). Episodes typically involve a temporary inability to move muscles in the arms and legs. The first attack usually occurs in childhood or adolescence. Attacks can last for hours or days, and the frequency of attacks varies among affected people. The frequency is usually highest between the ages of 15 and 35, and then decreases with age. Some people with HOKPP also develop late-onset proximal myopathy.
HOKPP can be caused bymutations in the CACNA1S, SCN4A, or KCNJ18 gene . Inheritance is autosomal dominant . Treatment varies depending on the intensity and duration of attacks. Minor attacks may resolve spontaneously, while treatment for moderate or severe attacks may involve ingesting oral potassium salts or intravenous potassium infusion.
Symptoms......Continued Here:
https://rarediseases.info.nih.gov/diseases/6729/hypokalemic-periodic-paralysis
HOKPP can be caused by
Symptoms......Continued Here:
https://rarediseases.info.nih.gov/diseases/6729/hypokalemic-periodic-paralysis