Three states of the voltage-sensing domain (VSD) of a membrane-channel protein. In the normal state, the water-accessible space (magenta) does not extend through the channel, preventing sodium (gray spheres) from passing through. In the disease state, a clear passage allows sodium to leakthrough, resulting in muscle paralysis. In the “rescued” state, the binding of guanidinium (blue and yellow spheres) effectively closes the channel and blocks sodium leakage. The red sphere represents the location of the disease-causing mutation. The side-chain sticks represent the voltage sensors of the sodium channel.
Please continued Here:https://als.lbl.gov/wp-content/uploads/2018/09/381.pdfHypokalemia- Hipopotasemia - نقص بوتاسيوم الدم - 低血鉀症 - Hypokaliämie - 低カリウム血症 - гипокалиемия - hipokaliemia - υποκαλιαιμία - hạ kali máu - хипокалемија - ipokaliemia - хипокалиемия - هیپوکالمی - היפּאָקאַלעמיאַ ***** The purpose of this blog is to collate all the key information regarding Hypokalemic Periodic Paralys, its symptoms, side effects and treatment. Information in English and Spanish. *****
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