HYPERKALEMIC PP VS HYPOKALEMIC PERODIC PARALYSIS

1. HYPERKALEMIC PERIODIC PARALYSIS MUTATED GENE SCN4A CHROMOSOME 17q DEFECTIVE CHANNEL SODIUM MODE OF INHERITENCE AUTOSOMAL DOMINANT 
2.  Hyperkalemic Periodic Paralysis • term hyperkalemic is misleading since patients are often normokalemic during attacks. • Onset first decade • M : F 1:1 • Attacks are brief and mild, usually lasting 30 minutes to 4 hours. • Weakness affects proximal muscles, sparing bulbar muscles. • Attacks are precipitated by rest following exercise and fasting. 
3.  In a variant of this disorder, the predominant symptom is myotonia without weakness (potassium-aggravated myotonia). • The symptoms are aggravated by cold, and myotonia makes the muscles stiff and painful. • Clinically apparent myotonia is seen less than 20% of patients, but electrical myotonia may be found in 50-75%. 
4. Pathophysiology  In hyperKPP, Na+ channels fail to inactivate and prolonged openings and depolarization result.  Increased extracellular K+ levels worsen the inactivation of Na+ channels.

Please continued Here: https://www.slideshare.net/laxmikantjoshi2/hypokalemic-periodic-paralysishpp